Platinum squares with high selectivity and affinity for human telomeric G-quadruplexes.
نویسندگان
چکیده
Two new Pt(II) squares with quinoxaline-bridges selectively stabilize human telomeric G-quadruplexes with high binding constants (10(7)-10(9) M(-1)) and an unprecedented binding stoichiometric ratio of Pt(II) square/G-quadruplex (6 : 1). This selectivity is likely due to the Pt(II) squares' cube-like shape. Both Pt(II) squares also show significant telomerase inhibition and anticancer efficacy.
منابع مشابه
Pt(II) squares as selective and effective human telomeric G-quadruplex binders and potential cancer therapeutics.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 61 شماره
صفحات -
تاریخ انتشار 2012